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The Osteoporosis and Cancer Connection part 1

The Osteoporosis and Cancer Connection Part 1


Surgery, chemotherapy, radiation, and hormonal therapy have side effects, which exacerbate the problems faced by cancer patients. Surgery can create adhesions that can limit range of motion, and cause pain, numbness and tightness. Removal of lymph nodes creates scars and may decrease range of motion and lead to lymphedema. Chemotherapy may affect balance, a patient’s immune system, and cause nausea, light-headedness, vertigo, neuropathy, fatigue, sarcopenia (loss of muscle mass), and anemia. Radiation can cause fatigue, tightness and stiffness. Hormonal therapy can cause joint pain and early menopause and the side effects associated with menopause. Surgery, chemotherapy and radiation can also increase the risk of developing osteoporosis.


Cancer surgery and treatments affect the entire body, not just the area of the cancer. Everyone has different reactions to the treatments. Sometimes the effects become apparent after the treatment is finished. Some symptoms can appear years later.

Among the problems associated with cancer is an increased risk for osteoporosis, or bone loss that increases the risk of fracture. Breast cancer and prostate cancer patients need to be made aware of their increased risk of osteoporosis and told what they can do to decrease their risk.


Osteoporosis means porous bone and is a chronic disease that weakens the bones. It is a serious health issue. With osteoporosis, bone density decreases and the bones become fragile and break easily. Although it can cause a break in any bone, the most common sites for breaks are the hips, spine and wrist. A broken hip or spine usually requires a hospital stay or surgery and can lead to permanent pain, disability, or death.


Bone loss occurs in everyone, as we get older. The leading causes of osteoporosis are decreased estrogen in women at menopause, and lowered testosterone levels in men. Bones loss speeds up during and after menopause as the protective effect of estrogen in the body declines. In fact, a woman can lose about 20 percent of her bone mass in the five to seven years after menopause.


The most common breast cancer is estrogen based. Cancer treatments work by starving the cancer of estrogen. The combination of the high incidence of breast cancer together with increased survival rates will increase the percentage of those suffering from breast cancer and osteoporosis.


The following cancer treatments can lead to a loss of bone density:


1. Aromatase inhibitors

Aromatase inhibitors are used in post-menopausal women diagnosed with hormone receptor positive cancer. In post-menopausal women, aromatase inhibitor agents to reduce the risks of cancer recurrence result in decreased estrogen and cause an increase risk of osteopenia/osteoporosis and fractures. Aromatase inhibitors inhibit aromatase from turning androgen into estrogen in other parts of the body besides the ovaries.

The aromatase inhibitors are: anastrozole (Arimidex), letrozole (Femara), and exemestane (Aromasin)


2. Androgen Deprivation Therapy

Androgen Deprivation Therapy hormone therapy leads to numerous side effects, which can be decreased through exercise. The side effects of ADT include loss of muscle, increase in fat mass and osteoporosis. A patient’s risk for diabetes and heart disease also increases. Men with prostate cancer who receive androgen deprivation therapy risk loss of bone density and fractures.


3. Chemotherapies

Chemotherapy has a major effect on bone health by shutting down the ovaries and causing early menopause in premenopausal women. The decreased estrogen state has a negative impact on bone density. Doxorubicin (Adriamycin), methotrexate (Trexall), cyclophosphamide (Cytoxan) and 5-fluorouracil can cause premature menopause.


4. Oophorectomy

The surgical removal of the ovaries will induce an early menopause.


5. Medically shutting down the ovaries

Used for hormone-receptor-positive breast cancer. Shutting down the ovaries decreases estrogen, in order to decrease cancer growth. Unfortunately, this leads to lower bone density, especially if the ovaries are shut down at an early age.

6. Use of corticosteroids

Some medications used to prevent nausea and vomiting may also have a negative impact on bone health.


7. Sedentary lifestyle due to cancer fatigue


Part 2 will be published on Monday

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